The Khairpur Rural Development Organization (KRDO) Sindh was established in 1995 and registered under the Social Welfare Agencies Registration and Control Ordinance 1961 in the year 1998 and he area of operation was extended from District to Provincial level vide Registration No: 1392 Dated 09th October 2012, Social Welfare Department, Government of Sindh Karachi.. The Khairpur Rural Development Organization name was derived from the name Khairpur State, which was merged in the year 1953 with Government of Pakistan under an agreement.

The KRDO has an experience to work with communities, governmental and non-governmental organizations and local government, in social mobilization, advocacy and service delivery.